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INHIBITOR, LUPUS COAGULATION
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DeCS
Descriptor
English
:
Lupus Coagulation Inhibitor
Descriptor
Spanish
:
Inhibidor de Coagulación del Lupus
Descriptor
Portuguese
:
Inibidor de Coagulação do Lúpus
Synonyms
English
:
Anticoagulant, Lupus
Coagulation Inhibitor, Lupus
Inhibitor, Lupus Coagulation
Lupus Anticoagulant
Tree Number:
D12.776.124.486.485.114.323.210.600
D12.776.124.790.651.114.323.210.600
D12.776.377.715.548.114.323.210.600
D23.113.475
Definition
English
:
An antiphospholipid antibody found in
association
with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;),
ANTIPHOSPHOLIPID SYNDROME
; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of
prothrombin
to
thrombin
and prolongs the
partial thromboplastin time
. In vivo, it exerts a procoagulant effect resulting in
thrombosis
mainly in the larger veins and
arteries
. It further causes obstetrical complications, including
fetal death
and spontaneous
abortion
, as well as a variety of hematologic and neurologic complications.
Indexing Annotation
English
:
DF: LUPUS COAG INHIB
Pharmacological Action:
Immunologic Factors
See Related
English
:
Antiphospholipid Syndrome
History Note
English
:
92; was LUPUS COAGULATION INHIBITOR (NM) 1978-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30002
Unique Identifier:
D016682
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS